VIM-15 and VIM-16, Two New VIM-2-Like Metallo-β-Lactamases in Pseudomonas aeruginosa Isolates from Bulgaria and Germany

VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany.

Two Pseudomonas aeruginosa urine isolates from Bulgaria and Germany produced two new VIM-2 variants. VIM-15 had one amino acid substitution (Tyr218Phe) which caused a significant increase in hydrolytic efficiency. The substitution Ser54Leu, characterizing VIM-16, showed no influence on enzyme activity. Both genes were part of class I integrons located in the chromosome.

Vim - 2 Β - Lactamase in Pseudomonas Aeruginosa Isolates from Zagreb

Nosocomial infections caused by multidrug-resistant Pseudomonas putida isolates producing VIM-2 and VIM-4 metallo-beta-lactamases.

1. DANMAP. DANMAP 2005-Use of Antimicrobial Agents and Occurrence of Antimicrobial Resistance in Bacteria from Food Animals, Foods, and Humans in Denmark. Danish Institute for Food and Veterinary Research, Copenhagen, Denmark, 2006. 2. Jensen LB, Hasman H, Agerso Y et al. First description of an oxyimino-cephalosporin-resistant, ESBL-carrying Escherichia coli isolated from meat sold in Denmark....

Emergence of metallo-β-lactamases GIM-1 and VIM in multidrug-resistant Pseudomonas aeruginosa in North Rhine-Westphalia, Germany.

stay, Patient A received successively piperacillin/tazobactam with vancomycin, cefepime with ciprofloxacin, and imipenem with ciprofloxacin, but Patient B only received amoxicillin/clavulanate (Figure 1). It is well established that K. pneumoniae isolates are an important reservoir of b-lactamases. Thus, the dissemination of the KPC carbapenemase has been linked to the dispersion of a clonal ST...

Prevalence of IMP and VIM Metallo-Beta-Lactamases in Pseudomonas aeruginosa Isolates from Clinical and Environmental Specimens in Intensive Care Units (ICUs) of Rasht Hospitals, Iran

Introduction: Pseudomonas aeruginosa is one of the leading causes of nosocomial infections, and antibiotic resistance of this pathogen is an important concern in treating such infections. The current work was conducted to investigate the prevalence of bla-IMP, and bla-VIM metallo-beta-lactamase (MBL) among clinical and environmental P. aeruginosa isolates obtained from ICUs of different hospita...